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The deformed ssn8 mutant cells resemble pseudohyphal structures.
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In particular, adult mutant β-cells resemble immature β-cells of newborn mice in gene expression and functional properties.
Quantitative analysis confirmed these differences and revealed that the chromatin structure of mutant cells closely resembles the nuclei from TE cells (Figure 6C).
The phenotypes of stc1Δ cells resemble those of RNAi mutants; however, artificially tethering Stc1 to a euchromatic locus promotes H3K9 methylation and heterochromatin formation independently of RNAi.
These cells resemble MM CSCs.
(A ) MP cells resemble mesodermally differentiated cells.
CD4+CD25-Foxp3+ T cells resemble regulatory rather than activated T cells.
Thus, mutant β-cells resembled β-cells isolated from newborn animals, but we did not detect evidence for a return to a progenitor state marked for instance by Ngn3 expression.
Proliferation curves of both mutant cell lines resembled that of the IC2 neg cells, with exponential growth and no plateau, indicating loss of contact inhibition.
Wells were then incubated with 50 µl of soluble ACE secreted from CHO cells transfected with wild type or mutant ACE or with lysates from these cells, resembling a membrane-bound form of ACE (wt and mutant).
These cells resembled to human AML blasts.
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