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Afterwards, the total number of cells were recounted and the difference between both counts equalled the number of mutant cells present.
The number of colonies is higher than the number of similar mutant cells present in the plated population, suggesting that growth limitation might be mutagenic.
Therefore, assuming that mutant cells are present, the probability (P M) that a mutant cell is chosen for reproduction at any given time is given by: where jdenotes the number of mutant cells present at that time.
Similar(57)
Nde1 mutant cells presented an entire array of genotoxic features including DSBs and chromosomal lesions that would ordinarily lead to carcinogenesis.
As observed in Figure 1C, and as expected from its more glycolytic phenotype, CYS12 mutant cells presented higher total levels of GLUT-1 as well as an increase in the glycosylated forms [ 23], when compared with ASP13 cells.
This could indicate that the double-mutant cells present additional defects than Rac1 mutant cells such as disarrangement of leading processes and impaired polarity.
Based on Figure 1, we would expect the large majority of these patients to have resistant mutant cells already present by the time of GIST detection and therefore to develop resistance during therapy.
The radioactivity associated with Fe-S proteins in Yae1-psd mutant cells is presented relative to that of WT cells.
This likely reflects the large proportion of (CA 26 mutant cells that are present within the M0 and M1 population.
Secondly, the spindle was frequently not recognisable in mitotic mutant cells and, when present, it exhibited significant defects in formation, being too short, without poles or bent.
Germ cell proliferation in the puf-8; gap-3; glp-1 RNAi) glp-1 RNAireduced to the level observed in glp-1 single mutant worms, and the fewasells preducedin toe thepleveltant differentiated intobserved(Fin. 6A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com