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Instead, the mutant cells appeared to have a blood vascular phenotype, as determined by their expression of laminin and CD34.
A noticeable fraction of the ΔrovA mutant cells appeared to be lysed, suggesting that the bacterial membranes might be constructed differently, thus unstable in the ΔrovA mutant under the experimental conditions employed, leading to the disruption of the bacterial cells.
Under HC environments, the Synechocystis WT and all Δflv mutant cells appeared much greener and grew much faster than under LC, and no obvious differences between WT and any of the Δflv mutants were observed in the amount of PSII centers (Figure 5A and 5B), even at irradiances as high as 200 µmol photons m−2 s−1 (data not shown).
Mutant cells appeared smaller than wild-type cells and were more rounded shaped.
The data also suggest that BRAFV600E mutant cells appeared to be more sensitive to the cytostatic effects mediated by MTA.
Xist clusters in control and Spen mutant cells appeared with similar efficiency, suggesting that Xist localization was not affected by the deletion of Spen.
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Interestingly, we observed that B52 mutant cells appear smaller than heterozygous cells, as demonstrated by staining of the apical periphery with anti-phospho-tyrosine antibody.
The mutant colonies that accumulate above a nongrowing lawn seem to result from new mutant cells appearing during selection, but may be initiated by pre-existing small-effect mutants and improved by secondary mutations that are common under all conditions.
The KRAS mutant cells appear to have less ability to deal with proteotoxic stress, possibly due to long-term increased basal levels of such stress and therefore reduced capacity of the proteasome to handle the effects of pharmacological proteasome inhibition.
Double-mutant cells appeared after the singly mutant cells reached the number needed to acquire the second mutation.
Accordingly, the genetic suppression mechanisms that we have defined for ATM-mutant cells appear distinct from those reported in BRCA1-mutant contexts, where suppression occurs specifically upon inactivation of the DNA-end resection and HR-antagonist protein 53BP1 and its interactors39,40,57,58.
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mutant cells suggested
mutant cells arose
mutant spindles appeared
mutant embryos appeared
mutant cells were
mutant mice appeared
mutant nuclei appeared
mutant nipples appeared
mutant placentas appeared
mutant parasites appeared
mutant colonies appeared
mutant NMJs appeared
mutant sensors appeared
mutant gonads appeared
mutant genotypes appeared
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