Sentence examples for mutant cells accumulated from inspiring English sources
Indeed, in the absence of any osmotic perturbation, Fps13A mutant cells accumulated ∼twofold as much glycerol as otherwise isogenic FPS1 + strains.
Under anaerobic conditions (as in Fig. 1), hemA mutant cells accumulated ruthenium to levels that are three-fold higher than wild-type cells (Fig. 2C).
DOI: http://dx.doi.org/10.7554/eLife.03790.014 Consistent with the SAGA-dependent effect of non-centromeric DNA circles on pore segregation in young cells, the sgf73∆ mutant cells accumulated NPCs slowly as they aged.
Cell-biological and biochemical evidence suggests impaired autophgay: mutant cells accumulated triacylglycerides and formed enlarged starch granules; they were devoid of autolysosomes although WT cells showed many; and they showed enlarged mitochondria.
A genetic screen for analyzing the role of the unfolded protein response (UPR) pathway in the yeast Saccharomyces cerevisiae identified a mutant (per5-1) with a glycosylation defect; the mutant cells accumulated M5-DLO and hypoglycosylated the N-glycoprotein carboxypeptidase Y (CPY) (27).
Acyl-group removal is necessary for efficient ER export via CopII coated vesicles, and Pgap1 mutant cells accumulate GPI-APs within the ER (Tanaka et al., 2004).
When cultured under autocrine conditions (serum-free) p53+/+ MEFs exposed to rapamycin accumulate in G1 phase and maintain viability, whereas p53-mutant cells accumulate in G1 phase and undergo apoptosis.
In the ovarian follicular epithelium, Ex is known to act in parallel with Kibra to regulate polarisation of Crb, such that ex, kib double-mutant cells accumulate Crb in vesicles (Fletcher et al, 2012).
To further explore whether His C mutant cells accumulate DNA damage and activate the DNA damage checkpoints, we stained for the phosphorylated histone variant H2Av (γH2Av), which is like its vertebrate ortholog γH2AX a marker of DNA damage (Madigan et al., 2002).
Mutant rqc1Δ cells accumulate a model substrate (GFP Arg12 RFP) with an internal polybasic tract that is designed to mimic an NSD pathway substrate, and Rqc1 and Cdc48 are shown to co-immunoprecipitate with this substrate.
When labelled wild type cells were mixed with rasD − mutant cells, the labelled cells accumulated in the pstO and pstB populations and were underrepresented in the prespore population.
