Sentence examples for mutant cannot bind from inspiring English sources

The empty form of the native protein is a transient intermediate bound to the nucleotide-exchange factor; since the T27N mutant cannot bind GTP, the complex is stable, the exchange process blocked and the cycling also when all the available nucleotide-exchange factor becomes complexed.

We agree with the Reviewer, however, that a demonstration that the FGF14bR/A mutant cannot bind NaV1.6 will enhance our manuscript.

The Δ2A mutant cannot bind to 7SK snRNP and therefore fails to suppress P-TEFb activity (He et al, 2008, Mol Cell).

As a result, the Δ2A mutant cannot bind to 7SK snRNP and fails to suppress P-TEFb activity (He et al., 2008).

However, the mutant cannot bind single stranded DNA, does not recruit some of the factors that are essential for origin activation, and it cannot support DNA replication and cell division.

Remarkably, the PICH-TA mutant showed the same re-localization to chromosome arms in response to Plk1 inhibition (Fig.  6a, b), in spite of the fact that this mutant cannot bind Plk1 and thus represents a poor substrate of this kinase (see also Fig. S 4B).

The function of mouse Apollo was determined using Cre-mediated gene deletion, complementation with Apollo mutants, and the TRF2-F120A muthat that cannot bind Apollo.

To address this question, we sought a ch-TOG mutant that cannot bind to the TACC domain of TACC3 and tested whether this mutant can track MT plus-ends.

Knockdown of BHC80 by RNA inhibition results in the de-repression of LSD1 target genes, and this repression is restored by the reintroduction of wild-type BHC80 but not by a PHD-finger mutant that cannot bind H3.

A stable c-Myc(T58A) mutant that cannot bind Pin1 or be dephosphorylated by PP2A replaces SV40 small T antigen in human cell transformation and tumorigenesis assays.

In contrast, neither the overexpression of Bmi1 nor expression of a Zfp277 deletion mutant which cannot bind to Bmi1 prevented the premature senescence of Zfp277−/− MEFs.