Sentence examples for mutant can induce from inspiring English sources

In conclusion, we have shown how an antibody raised against a kinetically unstable mutant can induce similar behaviour in the wild-type protein.

Similarly, the mouse ear tomato mutant can induce leaf phenotypic changes in wild-type grafting partner only when the mutant was used as the rootstock [ 22].

This is in agreement with previous studies reporting that neither an EGFR activating mutant nor a PTEN-null mutant can induce colony formation when expressed in MCF10A cells., It has also been shown that p53DD expression in hTERT-immortalized human mammary epithelial cells do not grow in soft agar.

The V1 and Sm2011exoY mutants can induce nodule-like structures but fail to infect them.

We found that full-length bbtCaspase-8 and two truncated mutants can induce apparent apoptosis, and that the apoptosis induced by full-length bbtCaspase-8 can be inhibited by the caspase-8 inhibitor z-IETD-fmk.

If Scrib does function upstream of aPKC in Drosophila, then either loss of Scrib promotes JNK activation independently of aPKC, or, alternatively, deregulated aPKC activity in scrib mutants can induce JNK-mediated cell death through a mechanism that is refractory to aPKCCAAXDN kinase dead -mediated inhibition.

These findings collectively demonstrate that the mutant EGFRT790M can induce lung tumor formation in the absence of additional gain-of-function EGFR kinase domain mutations.

It has not been proven however that mutant ASYN can induce CMA impairment in a cellular context, or that this effect could lead to lysosomal dysfunction.

Indeed, evidence that mutant proteins can induce neurodegeneration by an apoptotic mechanism in the absence of nuclear inclusions was first reported in a cellular model of Huntington's disease [44].

Mutant huntingtin can induce the precocious specification of a neuroectodermal fate (Nguyen et al., 2013).

Mutant p53 can induce cancer cell invasion by binding to p63 and inhibiting its transcriptional activity.