Previous studies have shown that mutation of receptor tyrosine residues to phenylalanine (such as in our Tie2 mutants) can affect kinase activity of the receptor.
Characterization of a few other Cx40 mutants linked to AF, such as G38D, I75F, P88S, A96S and L229M, strongly suggests that these mutants can affect the distribution and/or the function of gap junctions (Gollob et al., 2006; Sun et al., 2013).
Since p63 is a crucial transcriptional regulator of several epidermal genes and it has been demonstrated that AEC mutants can affect this function (45, 49– 51), we hypothesized that p63 may directly control expression of a subset of desmosome genes in addition to PERP, a previously identified p63 target gene (47).
To examine whether the mutant forms can affect regeneration of adult feathers, we injected the RCAS virus into flight feather follicles, after plucking resting phase feathers.
The present study is aimed at deciphering how the mutant IDH can affect cancer pathogenesis, in particular with respect to its associated oncometabolite D-2HG.
However, overexpression of mutant Ras proteins can affect other signalling pathways such as PI3K/Akt [22], that has been related to IM resistance [23], [24].
Altogether the data suggest that circadian fluctuations of PER-protein levels, such as those found in photoreceptor cell nuclei of wild-type and norpAP24-mutant flies [19], can affect lamina volume and photoreceptor terminals.
(E, F ) NLK can affect mutant AR phosphorylation in SBMA mouse muscle in vivo.
Also, in tai heterozygouts both the soma and the germline were mutant and the germline can affect via Notch signalling the size of the niche (Ward et al, 2006).
