Sentence examples for mutant can activate from inspiring English sources

Similarly, the L610D, L613D, and L617D Rabaptin-5C21 mutants cannot relieve the autoinhibition of Rabex-5; whereas the I608D Rabaptin-5C21 mutant can activate the GEF activity of Rabex-5.

This conclusion is partly based on genetic epistasis tests that indicated that MSB2 / HKR1 functions upstream of SHO1 : a constitutively active SHO1 mutant can activate Hog1 MAPK even in the msb2 Δ hkr1 Δ double-mutant cells, but a constitutively active MSB2 or HKR1 mutant cannot activate Hog1 in a sho1 Δ mutant.

Taken together, both Aurora-A and RasV12 mutant can activate the MEK/ERK1/2 signaling pathway.

Raf-1 S259 mutant can activate ERK to a similar extent as the v-Raf oncogene, yet fails to transform the cells, suggesting that the quality of the downstream signal is different depending on the upstream mode of activation (Dhillon et al, 2003).

(E ) In cell-based luciferase assays with M412 (blue bars), both WT and mutants can activate the expression of unmethylated M412 (blue bars), but have no effect on methylated M412 (red bars).

We show here that mutant WT1 can activate CCNB1 and CCNB2 expression, and this suggests that the mutant protein can antagonize the repression function of p53 at the Cyclin B promoter.

There is also evidence that mutant KRAS can activate NF- κB through IL-1 α and p62.

The data suggest that there are at least two different mechanisms by which mutant p110α can activate PI3K signaling.

Interestingly, in vitro experiments have shown that mutant p53 can activate the promoter of the MDR1 gene, which encodes P-gp.

Finally, studies in Drosophila have recently shown that mutant CHMP2B can activate the Toll-like receptor pathway (36): a process which has been implicated in neurodegeneration (37).

To test potential interaction site of EGCG in RIG-I, we tested RIG-I deletion mutants that can activate signal transduction in the absence of exogenous ligands.