Sentence examples for mutant by combining from inspiring English sources

We and other groups have sought to correct disease mutant by combining CRISPR/Cas9 and homology directed repair (HDR) in human tripronulcear zygotes and diploid zygotes.

Therefore, we analyzed whether it was possible to enhance the response and to overcome the resistance of the BCR/ABL-T315I mutant by combining the allosteric inhibition of GNF-2 with Dasatinib.

BUNCH (Petoukhov and Svergun, 2005 ) was employed to calculate a model of α-actinin-2 (for the wild-type and NEECK mutant) by combined rigid body and ab initio refinement of individual domain components against SAXS data.

Hence, our aim is to rationalize the experimental activity of known NNRTIs against a variety of RT mutants by combining molecular modeling, long-timescale atomistic molecular dynamics (MD) simulation sampling and ensemble docking.

Third, we created a collection of double mutants by combining mutations of known fitness effects and evaluated the intensity and nature of epistasis.

We also created double mutants by combining pairs of these single mutations and found variation in the magnitude and sign of epistatic interactions, with an enrichment of cases of positive epistasis.

Recent work by the Wellcome Trust Sanger Institute's Zebrafish Mutation Project has demonstrated the sensitivity and scalability of RNA-seq for high-throughput mutant analysis by combining exon-resequencing with morphological phenotype analysis (www.sanger.ac.uk/Projects/D_rerio/zmp/).sanger.ac.uk/Projects/D_rerio/zmp/

The E35Q/H300N double mutant was constructed by combining the pGTacStEH1-5H-based mutants E35Q and H300N.

A CotA double mutant, K316N/D500G, was constructed by combining random and site-directed mutagenesis.

A double mutant (R53T/R73A) was also produced by combining the 2 substitutions of the single mutants.

Typically, phenotypes become detectable by combining mutants in multiple WRKY genes or by over-expression analyses [ 25].