Sentence examples for mutant blocks the from inspiring English sources

Furthermore, this kinase-inactive mutant blocks the translocation of RPA in a cell cycle-dependent manner.

Finally, a dominant-negative ARF1 mutant blocks the migration of the Nef-CD4 complex to lysosomes.

If one lysine mutant blocks the ubiquitination of HSP70, it would suggest that the ubiquitination of HSP70 utilizes that specific lysine linkage.

Figure 1A shows that Cry1Ab-D136N/T143D mutant blocked the action of Cry1Aa, Cry1Ac and Cry1Fa toxins, but did not affect the toxicity of Cry1Ca, Cry1D or Cry1Ea.

In contrast, expression of the S270A mutant blocked the endogenous phosphorylation of nSMase1 (lane 4, Supplementary Figure S7a).

Notably, the expression of the DARPP-32 T153A mutant blocked the decrease in c-fos expression by restoring CREB phosphorylation (Fig. 5A, B, D, E).

Transfection of myocytes with an adenovirus-IkB super repressor mutant blocked the augmentation of NFkB activity and of IL6 mRNA expression by palmitate [ 162].

Transfection with the serine mutant blocked the effects of TGFβ1 on dendrite elongation and GABAergic connectivity, whereas transfection with the tyrosine mutant of I-κBα had no effect on TGFβ1 activity.

Our results revealed that HSP70 utilizes K63 linkage to assemble polyubiquitin chains to bind to p62's UBA domain since only the K63R ubiquitin mutant blocked the ubiquitination of HSP70 (Fig. 8A).

Krishnan et al. [ 24] found that transfection of the ezrin-Thr-567A mutant blocked the ezrinThr-567-inhibited metastases in Ewing's sarcoma, suggesting that ezrinThr-567 is closely related to malignancy metastasis.

Depletion of μ2 or CLTC, as seen similarly in cells transfected with the Rab5 dominant-negative mutant, blocked the endocytosis of KIAA0319, indicating that the pool of KIAA0319 localized on the plasma membrane is indeed internalized via the clathrin pathway using AP-2 as an adaptor.