Sentence examples for mutant blocked the from inspiring English sources
Figure 1A shows that Cry1Ab-D136N/T143D mutant blocked the action of Cry1Aa, Cry1Ac and Cry1Fa toxins, but did not affect the toxicity of Cry1Ca, Cry1D or Cry1Ea.
In contrast, expression of the S270A mutant blocked the endogenous phosphorylation of nSMase1 (lane 4, Supplementary Figure S7a).
Transfection of myocytes with an adenovirus-IkB super repressor mutant blocked the augmentation of NFkB activity and of IL6 mRNA expression by palmitate [ 162].
Notably, the expression of the DARPP-32 T153A mutant blocked the decrease in c-fos expression by restoring CREB phosphorylation (Fig. 5A, B, D, E).
Our results revealed that HSP70 utilizes K63 linkage to assemble polyubiquitin chains to bind to p62's UBA domain since only the K63R ubiquitin mutant blocked the ubiquitination of HSP70 (Fig. 8A).
Krishnan et al. [ 24] found that transfection of the ezrin-Thr-567A mutant blocked the ezrinThr-567-inhibited metastases in Ewing's sarcoma, suggesting that ezrinThr-567 is closely related to malignancy metastasis.
Both wild-type TSC2 and the phosphorylation-site mutants blocked the constitutive, growth factor-independent mTORC1 activity in Tsc2-deficient cells, as monitored by S6K1 and S6 phosphoryation and 4E-BP1 mobility shifts indicative of phosphorylation status (Figure 5C).
Similarly, it was demonstrated that PSEN but not APP mutants blocked the effects of γ-secretase modulators (GSMs), which preferentially reduce the amyloidogenic Aβ42 species but spare proteolytic processing of the γ-secretase substrate NOTCH [ 94, 97- 100].
Alternatively, the relationship between ept and Dome localization could indicate a direct requirement for ept in Dome endolysosomal trafficking in much the same way that ESCRT mutants block the vesicular movement and lysosomal turnover of the Notch receptor [4] [6], [47].
Loss-of-function sur2 mutants block the production of glucosinolates from IAOx, leading to an increased IAOx flux for IAA biosynthesis.
Based on those previous results and the lack of association signals in the stopped-flow experiment, the three Rap1 mutants are well suited as mutants blocking the interaction between Rap1 and Rap1GAP.
