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This work was made possible by funds to J.P.M. from the Swiss National Science Foundation (grant 125370) and from the Italian Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) through the grant FIRB 2010 (RBFR10S1LJ_001) to A.C. We wish to thank Prof Chung-Mo Park (Seoul National University) for making the myb96-1 mutavailableable to us.
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The armory of GFP mutants available to biochemists and molecular biologists is huge.
This library will enable mouse mutants to be established worldwide in a standardized and cost-effective manner, making mouse mutants available to a much wider biomedical research community.
I would not have set that programme up without there being a clear understanding that we would make the mutants available to anyone that wanted access to them.
To further analyze and complement gene function, studies are necessary with adequate transgenic grapevines (since there are no knock-out mutants available) to prove expansin effects on the gall formation upon phylloxera infection.
It should be finally remembered that most of the experiments described here were performed with mouse NBD1, because its ΔF508 mutant was available to us while the human ΔF508 mutant was not.
Unfortunately, no cxcr7 mutant is available to test directly this hypothesis.
Furthermore, reducing chaperone involvement in ERAD might increase the population of mutant proteins available to be rescued.
One of the most important things about the project is that these mouse mutants are available to other people so that they can study them in more detail and add value to those mutants.
Therefore, the relevance of D. melanogaster to human cardiovascular research would be enhanced if methods and mutants were available to demonstrate quantitative heart wall motion defects given their relevance to clinical medicine.
The predicted hydrogen bond interaction formed by a small molecule inhibitor with mutant Ser797 is available to design the fourth-generation EGFR-TKIs.
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