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Crizotinib itself may be considered for this purpose, but it does not inhibit EGFR [40] (although is does bind the EGFR G719C mutant at micromolar levels).
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Some DANAs were also active at micromolar concentrations against the K103N + Y181C resistant mutant.
Punj, D. et al. A plasmonic 'antenna-in-box' platform for enhanced single-molecule analysis at micromolar concentrations.
Wang, R., Xing, X. & Crawford, N. Nitrite acts as a transcriptome signal at micromolar concentrations in Arabidopsis roots.
However, cathepsin H was inhibited at micromolar concentration.
However, in 2004, SUCNR1 was deorphanised and found to be activated by the citric acid cycle intermediate succinate at micromolar concentrations2.
For short-lived radiometals, this concentration typically is at micromolar level.
All the synthesis were carried out at micromolar level at 37 °C and then stored at 4 °C [22].
Niclosamide is also potent, with sub-micromolar activity while the other three chemicals inhibit mTORC1 at micromolar concentrations.
Cocaine inhibits these transporters with similar potencies at micromolar or submicromolar levels [4].
At micromolar range, however, icaritin inhibited growth of prostate cancer PC-3 cells [12].
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