Sentence examples for mutant at codon from inspiring English sources

One of these mutant tumors was found to be KRAS mutant at codon 12 (Gly > Ala) as well [Figure 3 & 4].

MCF7, which express a WT variant of p53, KAT-4, which bears a p53 variant mutated at codon 273 (C GT→C AT; Arg→His), BHT101, which expresses a p53 mutant at codon 251 (A TC→A CC; Ile→Thr) and FRO cells, which do not express p53 at all, were cultured in Dulbecco's minimal essential medium (DMEM) supplemented with 10% foetal bovine serum (FBS) at 37 °C in 95% air – 5%CO2.

In the symptomatic group 96% of parasites carried the triple dhfr mutant haplotype (mutants at codons 51, 59 and 108) (Table 4) showing near saturation of this haplotype.

Bst 71I & Hpy CH4V digested GGC to AGC & CGT to CAT mutants at codons 245 (exon 7) and 273 (exon 8), respectively.

In addition, mutant alleles at codons 51 and 59 were also detected at high frequencies (85% – 98%).

The sequence alteration in the mex-1 or286 mex-1 or286changed a glutsmutantt changed3 to a stop codon (Figlutamine Tatle 2).

We previously showed that the GSS-associated A117V PrP mutant with a valine at codon 129 retained the anti-Bax function while all of the 11 CJD-associated PrP mutations carrying a methionine at codon 129 or the FFI-associated D178N PrP mutant lost the ability to prevent Bax-mediated condensed chromatin in human neurons [31].

Adenomas in Apc 1322T mutant mice are larger, more numerous and of earlier onset than those from Apc Min animals in which the mutant protein is truncated at codon 850 and lacks all β-catenin binding repeats.

We amplified the cDNA of the PTC-STOP region of one clinically identified BRCA1 mutant (with a PTC at codon 526) (Perrin-Vidoz et al., 2002) and fused it to the 3′ end of a firefly luciferase coding region to create a chimera such that the original stop codon of the luciferase gene serves as a PTC in the fused reporter.

7, 8 In contrast to these mutants, mice with the third mutant allele, containing the missense at codon 326, exhibited a unique tumor spectrum.

We previously have shown that eleven CJD-associated PrP mutants with a methionine at codon 129, partially or completely lost their anti-Bax function but that this loss of function could be rescued by co-expressing the CJD mutant PrP with WT CyPrP or its cognate mutant CyPrP [31].