Pol, A. et al. A caveolin dominant-negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance.
However, unlike USP20 WT and S333D, the S333A mutant associated poorly with the β1AR and failed to deubiquitinate the β1AR.
Defects in heme-binding were also observed with the MLS-associated E159K HCCS mutant; however, the synthetase activity of this mutant varied widely from 10%to7070% WT levels, depending on the culture volumes used to measure the HCCS-mediated release of matured cytochrome c (Table S2).
Waki, H. et al. Impaired multimerization of human adiponectin mutants associated with diabetes.
Similar results were obtained with 23 mutants associated with nucleotide biosynthesis from PRPP and/or L-glutamine (Figure 3B).
This latter response suggested that Afh mutant mice were able to associate the moment of the meal with the light on (e.g., learning of the stimulus-response association), however, an alternative explanation of this response relates to the high sensitivity of Afh mice to light22.
With the mutant bacteria, however, the compartments were smaller and disappeared shortly after the cells were infected.
M. jannaschii Hfq is generally able to complement a Salmonella hfq null mutant; however, the distribution of associated sRNAs recovered from pull-down experiments varies greatly compared to the wild-type.
Col1a2 and Il6 are significantly downregulated in gnz and bkr mutants; however, phenotypes associated with mutation of these genes in humans are unrelated to forebrain development (Dickson et al., 1984; Wirtz et al., 1987; Kishimoto, 2005).
Investigations into the molecular properties of the katun mutant protein confirmed, however, that it lacks activities associated with wild-type ZIC3.
