Sentence examples for mutant as judged from inspiring English sources

The fusion complements a Blm10 deletion mutant as judged by its total relief of hypersensitivity to phleomycin.

We did not detect any substantial change in microtubule organization in the Neurl4 mutant, as judged by the distribution of the Kin-lacZ fusion protein.

Intriguingly, the levels of Smc ScpAB entrapping chromosomal DNA were strongly reduced in the parB null mutant as judged by the limited retention of Smc ScpA species in agarose plugs.

The CiaD-ACD fusion protein was secreted from the C. jejuni wild-type strain and a ciaD mutant but not the flgBC flagellar mutant, as judged by immunoblot analysis using an ACD specific antibody.

We generated the TRIP13E253Q/W221A double mutant in order to test the role of the pore loop in p31(comet):MAD2 binding but found that, unexpectedly, this mutant does not form a stable hexamer like the TRIP13E253Q mutant (as judged by elution on a size exclusion column in the presence of nucleotide).

Fast local motions (ps-ns) and slower long-range conformational dynamics (μs-ms) were altered in some mutants as judged by NMR.

In particular, the single tryptophan residue, located near the end of helix IV, and distant from helix III, is in a distinct environment in the two sets of mutants as judged by fluorescence, near-UV CD and the sensitivity of tryptophan fluorescence to iodide quenching.

At E10.5, dorsoventral patterning proceeded normally in ATF2 mutants as judged by the expression pattern of Nkx2.2, Isl-1, Pax6 and Pax7 which was similar to that in heterozygotes.

At P3, the numbers of Mbp- and Plp-positive cells were still reduced in the Sox2 ΔSox10 and Sox3 ΔSox10 mutants as judged both by ISH (Fig. 5C,F,I,L,O,R,S,U) and immunohistochemistry (Fig. 5T,V,W).

However, no changes in telomerase enzymatic activity were observed by expression of the mutant protein as judged by TRAP (Fig. 3B), indicating that NES-hTERT does not exert a dominant negative effect upon the endogenous protein at least in terms of enzymatic activity.

Interestingly, striking differences could be observed when we compared the morphology of motor neurons transduced with WT-HSPB8 with those expressing mutant HSPB8, as judged by SMI32 neurofilament immunostaining.