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Presenilin proteases gained substantial interest following identification of presenilin mutants being causative for some forms of familial Alzheimer disease [ 34].
If the miRNAs absence in the mutants was causative of the lifespan phenotype, then these transgenic animals should be rescued for that phenotype or otherwise show a modulation of lifespan.
And so these plaques are causative.
Genomic differences common to both isolates represent the evolutionary distance between the WT and the mediator and are therefore discarded, while changes unique to the mutant are further investigated, as they may be causative.
However, other bacteria may also be causative.
The genetic results thus provide strong supporting data to conclude that the nucleotide changes identified are causative for the functional phenotypes observed in these mutants.
Further analysis will identify the specific genes that are causative of the different phenotypes shown by the RNAi mutants.
Several gene mutations are causative of the familiar form of the disease and the corresponding mutant proteins often mislocalize and aggregate in the cytoplasm.
To test if the identified deletion in mpv17 is causative for the tra mutant phenotype, we injected one-cell stage mutant embryos with in vitro transcribed mpv17 mRNA at a concentration of 100 ng/µl.
These results support the hypothesis that bony compression is causative for impaired vision in Tcirg1−/− mutant mice.
These results suggest that the abnormal neural fold morphology may be causative for the delay in PNP closure in hitchhiker mutants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com