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More recently, Men et al. [27] showed that defective sterol profiles in the cpi1-1 mutare associatedated with defective PIN2 endocytosis and polar localization following cytokinesis.
Interestingly, AtARF6 and 8 (double mutant) are associated with floral development in Arabidopsis [ 33].
In contrast, Rab7-Q67L never occurred in two copies, indicating that high levels of this constitutively active mutant are associated with reduced fitness.
By contrast, the large changes in protein and amino acid synthesis in o2, replicated also in the o2o7 double mutant, are associated with large changes in the patterns of gene expression.
That is, higher levels of PER and TIMΔNLS in the mutant are associated with levels of repression that are typically seen in response to much lower levels of total accumulated PER and TIM in wild-type flies.
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A reduced theoretical pKa value and a lowered experimental pH optimum of hydrolytic rates for the D346A mutant were associated with a 9-fold increase in VmS/VmH.
In this respect, it can be speculated that the unusual leaf variegation phenotype in the z3 mutant is associated with metal ions which play a key role in chlorophyll biosynthesis.
Elimination of activity toward primed substrates only using the GSK-3 R96A mutant was associated with a defect in axon polarity (axon branching) compared to an overall reduction in axon growth induced by a kinase-dead mutant.
The delayed activation of the SA defense pathway in the mutant was associated with its susceptibility.
Overexpression of a normoxically stable HIF-1α mutant was associated with mildly increased luciferase activity.
This result, however, is in contrast to the recent report that S935A mutant was associated with punta localization in COS-7 cells [24], [25].
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