Sentence examples for mutant app is from inspiring English sources

Or make more extensive changes — the resultant mutant app is saved under your own profile.

Notably, the T668A mutant APP is able to bind Mint1.

The combined data prove that mutant APP is only marginally potent and on a much longer time-scale, relative to protein Tau in provoking damage to pyramidal neurons, under very comparable experimental conditions.

Moreover, in vitro studies demonstrated that the AD-associated Swedish mutant APP is associated with increased BACE1 activity developing the phenotypes typical of axonal transport defects because of an enhanced cleavage of APP.

Mice overexpressing mutant APP were crossed with mice heterozygous for sod2, resulting in strains of mice with acceleration of amyloid accumulation, in addition to increasing behavioral defects in one strain [26].

In cell cultures overexpressing this mutant, BACE cleavage of the mutant APP was decreased by 50%, thereby decreasing Aβ production.

The Sar-soluble (Fig.  6f) and insoluble (Fig.  6g) tau bands of cells expressing F690P mutant APP were quantitatively more intense than those of cells expressing WT-APP.

We propose that the higher levels of the mature mutant APP are mainly attributable to a prolonged half-life enabled by reduced ectodomain shedding.

Cells expressing both tau and WT-APP or the F690P mutant APP were treated with tau fibrils (1 μg/mL) for 1 h, and cultured for 72 h after medium change.

It could be argued that the effects on tau elicited by co-expression of mutant APP are, in fact, not due to Aβ but rather to APP or other fragments generated in the process of proteolytic cleavage of APP.

Mice with the mutant APP were identified by genotyping, and amyloid plaque formation was verified in all animals designated as 'Alzheimer's mice' after the dye-labelled cells were counted.