Sentence examples for mutant animals when from inspiring English sources
The mean weekly increase in body weight was significantly high in ad libitum-fed mutant animals when compared with control littermates, whereas pair-fed mutant animals showed no difference to control littermates (Fig. 2D).
In fact, both bone mineral content (BMC) and bone mineral density (BMD) are significantly lower in mutant animals when compared to wild-type littermates (Figs. 1, panels D and E).
Similar analysis for the H3K9me3 ChIP-seq assay revealed that the 23 °C-generations samples had a modest but consistent reduction of H3K9me3 levels for NHGs in both the wild-type and the hrde- 1 mutant animals when compared with the 15C-G3 sample (Additional file 5).
The food source does not account for this difference; in contrast to the context of daf-2 RNAi, daf-12 (null) mutation did not shorten the life spans of daf-2 (e1368 ) ; daf-36 (null) mutant animals when animals were grown on E. coli HT115 [ Figure 4C and Table S2; 0% change in median life span comparing daf-2 (e1368 ) ; daf-36 (null); daf-12 null) daf-12 null1368 ) ; daf-36 (null), P = 0.6097].
Likewise, germline development of smc-5 mutant animals is impaired when worms are grown on plates containing HU.
Having constitutively high SQRD-1 levels, as in egl-9 mutant animals, allows survival when wild-type animals with lower HIF-1 activity would perish.
Interestingly, at the time when mutant animals were exposed to PT (at P8), they had high TB levels (12.5±0.9 mg/dl; Fig. 1E and supplementary material Table S1) and did not show an important reduction in PC number (Fig. 2C).
Of significance here, the concentration of Mg2+ in the hemolymph approximately doubled when the mutant animals were fed high mM Mg2+ (Figure 3A).
When the mutant animals are subjected to voluntary wheel running, they show distorted day night rhythm; they exhibit continued activity after the light is turned on (delayed activity) and untimely activity before the light is turned off (anticipatory activity).
The experiments were conducted at an early symptomatic disease stage (6 weeks) when the mutant animals developed mild ataxia, and PC loss was yet to be observed (6).
Cresyl violet staining confirmed dramatic rhombic lip and EGL abnormalities (Aldinger et al., 2009) at all stages, however we also noted extensive additional abnormalities of the cerebellar ventricular zone and its derivatives in mutant animals as early at e13.5, when cerebellar anlage size and shape differences were readily apparent.
