The NSCs within this area were dispersed and disorganized in mutant animals, suggesting that Idh1-R132H perthebed the NSCs and the microenvironment from which gliomas arise.
Pharynx morphology and resistance to mechanical stress seemed normal in the agr-1 (eg1770) mutant animals, suggesting that agrin is not essential for proper development or structural support.
Interesting heart phenotypes and axial skeleton phenotypes were observed in Asxl2 mutant animals, suggesting that the expression of the gene trap in the heart and in the axial skeleton is probably reflective of endogenous expression and function in these tissues.
Significantly, atg6 mutant larvae expressing activated Trc displayed decreased formation of blood cell mass in contrast to control atg6 mutant animals, suggesting Trc can function downstream of Atg6.
The elevated levels of phosphorylated smad and BMP receptors in spichthyin mutant animals suggests that spichthyin antagonizes BMP signaling by regulating its receptor traffic.
Bcl11b mutant animals again exhibited a high locomotor activity but no significant difference in entering protected or unprotected arms between control and mutant animals, suggesting that there is no difference in anxiety-related behaviour.
Importantly, the inability of tir-1 RNAi treatment to increase further the arsenite-sensitivity of pmk-1 mutant animals suggests impaired PMK-1 activation underlies the arsenite-sensitivity of TIR-1-deficient animals.
In addition, the diffuse GFP RAB-3 phenotype was fully rescued when wild-type snt-1 was introduced into mutant animals, suGFP RAB-3that SNT-1 is indeed essential for localization of RAB-3 on SVs.
Nevertheless, the levels of other DILP genes, especially DILP1, were elevated in DILP6 mutant animals, suggesting that compensatory mechanisms may exist that may reduce the severity of DILP6 loss of function.
(C ) Quantitation of third and fourth larval stages of the ced-3 lf);ain-1(lf) ced-3 lfutain-1 lfals ain-1 lf supernumerary seam cells continue to arise double late larval stages.
