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These delays could be rescued by feeding 20-hydroxyecdysone to the mutant animals indicating a defect in prothoracic gland function and ecdysone release in itpr mutants [3].
OMA-1::S TEV::GFP is able to restore fertility to oma-1 ; oma-2 mutant animals, indicating that it functions properly in vivo.
Moreover, UNC-70(TSMod) rescued the severely paralyzed locomotion phenotype of unc-70 null mutant animals, indicating that the fusion protein is functional (Krieg et al., 2014).
Cell-specific expression of SER-3 in the SIA neurons rescued exogenous octopamine and food responses of ser-3 mutant animals, indicating that SER-3 works in the SIA neurons to receive octopamine signaling.
However, the cellularity of the regenerated epithelium in naphthalene-treated Hoxa5−/− mice remained similar to that from untreated mutant animals indicating that mesenchymal Hoxa5 expression is necessary for correct lung airway re-epithelialisation and differentiation.
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However, investigation of the visceral muscle fusion process in ΔC3GMS mutant animals indicates that C3G activity is not essential for this process (Figure S2 C and D).
The lethality of disruption of the MRN genes in mice compared to the viability of ATM null mutant animals indicates a clear difference in the nature of the underlying genes.
Any feeding rate difference between wild-type and the ser-7 mutant animals indicates active serotonin signaling via SER-7 because ser-7 specifically affects serotonergic signaling, with some contribution from basal activity of SER-7 in the absence of serotonin (Hobson et al., 2003).
Group 3: For what purpose did Polley and Fay produce the double- and triple-mutant animals indicated in figure 1, B D, in the accompanying article?
Interestingly, both behavioral and electrophysiological studies find that the response to MHC ligands is similar in wild-type and TrpC2-/ mutant animals [57] indicating that the response to MHC peptides is independent of TrpC2 function.
Myo15 transcript levels are comparable between mutant and wild-type animals, indicating that the protein function of myosin XV must be altered.
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