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Double mutant analysis indicates that Gli3 repressor activity is normal in hnn embryos, but Gli activators are constitutively active at low levels.
Thus, the mutant analysis indicates that BicD's role in balancing plus-end versus minus-end motion is functionally separable from its role in facilitating overall upregulation of transport, with the resulting long runs in each direction in Phase IIB (Fig. 6H, I).
Mutant analysis indicates that Dga1 contributes more significantly to TAG synthesis in the stationary phase, whereas Lro1 apparently is more active during logarithmic growth (Oelkers et al. 2002).
Double mutant analysis indicates a possible synergistic interaction between svr3 and svr7, which is defective in a chloroplast pentatricopeptide repeat (PPR) protein.
While our findings indicate that the expression of otd is relatively low compared to the level of ems expression in the ALl1 neuroblast, our mutant analysis indicates that otd is essential for the development of the neurons in this lineage.
We are currently unable to define where in the pathway this effect is occurring, though our mutant analysis indicates differences in the sensitivity of interfering and non-interfering repair to sequence polymorphism.
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Double mutant analysis indicated that SRL2 and SLL1/RL9 function in different ways to regulate abaxial-side leaf development (Liu et al. 2016).
In case of Δ vvd, both the enrichment of carbohydrate metabolism genes, as well as the beneficial effect of several genes on cellulose degradation, as revealed by mutant analysis, indicate that the reason for enhanced cellulose degradation by the Δ vvd mutant lies at least in part in increased expression level of hydrolytic enzymes.
As opposed to the single and double mutants, QCC-NCA analysis indicates that the heme in A7F (−0.65 Å) is less ruffled than that of wt (−0.78 Å).
Counterintuitively, the BB mutant of Drosophila Merlin is known to be inactive in suppressing cell proliferation, yet our structure-based analysis indicates that the mutant Merlin should adopt a more open conformation and thus more active in suppressing cell growth.
Our analysis indicates that the mutants that impair function can be grouped into three classes.
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