Sentence examples for mutant alleles only from inspiring English sources

Although chic05205 and chic221 are well established strong loss-of-function mutant alleles, only chic221 is a molecularly confirmed null allele (Materials and Methods).

In our study, we detected Ki-ras mutant alleles only in four out of 10 patients with high CA 19-9 levels.

In this way, we established populations that were outbred and contained either only Hsp83 mutant alleles, only wild-type alleles (See additional file 7A, "between-line" crosses), or a 1 1 mix of mutant and wild-type alleles (See additional file 7A, "between-genotype" crosses).

Several different defects were scored for the different xpd mutant alleles, but only defects that arose in a nucleus that previously did not show defects were counted for the statistics (Figs 4, 5).

Within the GCR2 gene family, mutant alleles for only GCR2 and GCL1 have been reported previously [8], [9].

Within the RACK1 gene family, mutant alleles for only RACK1A have been reported previously [ 15].

To our knowledge, this is the first study showing the detection of rare mutant alleles from only few milliliters (200  μL) of serum or plasma.

9 Although PRPF31 is ubiquitously expressed, patients with mutant PRPF31 alleles only show symptoms in the retina and not in other organs.

All variants were heterozygous and detectable in both metastases (9/9 variants) and the corresponding cell lines H-STS (9/9) and P-STS (9/9) at lower passages (passage 7 for H-STS, and 14 for P-STS; Table 2) whereas the L-STS at passage 9 has already lost the mutant alleles and displayed only reference/wild-type allele information (Table 2) for all nine investigated markers.

Before the molecular cloning of Hd1, it was demonstrated that near-isogenic lines containing hd1 mutant alleles exhibited not only delayed flowering under SD conditions but also early flowering under LD conditions, indicating that Hd1 could repress flowering under LD and that Hd1 function is modified depending on day length [46].

We did not recover mutant alleles that affect only the large isoform.