Sentence examples for mutant Aβ model from inspiring English sources

MD simulations of the V18A/F19A/F20A (MA) and V18L/F19L/F20L (ML) models of Aβ(13 26) were carried out at 360 K. Five independent MD simulations were performed for each mutant Aβ model (Table 1).

In order to gain a better understanding of the molecular mechanism of the unfolding of the Aβ central helix, the wild-type (WT) Aβ(13 26) model was compared with mutant Aβ(13 26) models with alanine (MA) or leucine (ML) replacements at three nonpolar residues 18, 19, and 20.

The structures of the mutant Aβ(13 26) models were built by modifying the WT Aβ(13 26) model with V18A/F19A/F20A or V18L/F19L/F20L replacements.

Ejby, Denmark; N = 4 TG females, 3 WT females) express the human 695 isoform of APPswe, which leads to expression of mutant Aβ, Aβ plaques and memory deficits.

The mutant Aβ peptide, Aβ 40ARCTIC, is more prone to oligomerization than wild-type Aβ 40 [4], whereas PD-associated mutations promote α-synuclein aggregation [3].

Interestingly Hebbar et al. [11] who showed that a double mutant Aβ peptide (R5A/Y10A) did not bind to GalCer.

Furthermore, the propensity of mutant Aβ to form different polymorphic aggregates may underlie the phenotypic variations associated with these mutations.

We studied the in vitro aggregation properties of synthetic Aβ peptide carrying the E682K mutation (E11K mutant Aβ).

AV, KB and IB characterized the aggregation property and cytotoxicity of mutant Aβ peptide in vitro.

In transgenic mice (Tg-SwDI) that accumulate human Dutch/Iowa (E22Q/D23N) mutant Aβ, both human apoE3 and apoE4 strongly shifted the Aβ deposition from CAA into plaques [ 38].

Mutant Aβ in some forms of familial CAA is resistant to degradation by neprilysin and thus may increase the amount of Aβ draining along perivascular pathways [ 52].