Sentence examples for mutagenicity testing in from inspiring English sources
Although the latter protocol is commonly used for mutagenicity testing in somatic tissues, it has several shortcomings for germ cell testing because it provides limited exposure of the proliferating phase of spermatogenesis when mutations are fixed in the transgene.
As reviewed by Zeiger (2004), many factors led to the initial effort of the U.S. government, in particular, M. Legator at the FDA, to sponsor mutagenicity testing in 1971, followed by numerous contracts in the ensuing years.
Our review of these data indicates adequate sensitivity of batteries of in vitro short-term mutagenicity tests in identifying germ cell mutagens.
PC showed a significant (P < 0.005) inhibition of BP- and 2AF-induced mutagenicity tested in the presence of S9 mix.
Recent advances in genetic toxicity (mutagenicity) testing methods and in approaches to performing risk assessment are prompting a renewed effort to harmonize genotoxicity risk assessment across the world.
In mutagenicity testing, critical mutation frequencies are defined in terms of multiples of SDs of background mutation rates (Venitt and Parry 1984).
Witwer attended partly in hopes of meeting biochemist Bruce Ames, inventor of the Ames mutagenicity test, identified in OMICS material as a speaker.
Until recently, mutagenicity testing was done on preselected compounds in a manner in which the testing laboratories knew the identity of the substances under test and the "expected" results, i.e., positive for compounds selected because of their carcinogenicity and negative for food additives.
The usefulness of the tester strain TA102 in routine mutagenicity testing is discussed.
Thus there is raised a serious question concerning the reliability of quantitative data published in bacterial mutagenicity testing where replica testing of the histidine requirement of the resulting "revertant" colonies is not routinely made.
It is suggested that the replica technique can easily be developed as a simple and useful tool for the control of histidine requirement and ampicillin resistance in routine mutagenicity testing.
