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However, some kinds of tannins can reduce the mutagenicity of a number of mutagens and also exhibited antioxidant, anticarcinogenic and antimicrobial activities [41].
Next, the collaborating laboratories used the PIGRET and RBC Pig-a assays to assess the mutagenicity of a total of 24 chemicals in rats, using a single treatment design and mutant analysis at 1, 2, and 4 weeks after the treatment.
The antimutagenic ∕antigenotoxic potential of HK were also tested against the mutagenicity of a variety of direct and indirect acting mutagens, such as 4- nitro- o-phenylenediamine (NOPD), sodium azide (SA), mitomycin C (MMC), benzo[ a]pyrene (B[ a]P), aflatoxin B1 (AFB1), 2-aminoanthracene (2-AA) and 2-aminofluorene (2-AF), by the Ames test, and doxorubicin (DXR) by the comet assay.
Herein, we evaluated the mutagenicity of a series of 7-azabicyclo[2.2.1]heptane 7-azabicyclo[2.2.1]heptane monocyclic nitrosamines by using the ands assay.
However the presence of such alerts alone is not a definitive method to prove the mutagenicity of a compound towards Salmonella, since other parts of the molecule can influence and potentially change the classification.
This study tracked changes in the mutagenicity of a PAH-contaminated gasworks soil throughout the course of a pilot-scale bioremediation.
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The mutagenicity of an adduct is also affected by its location within a DNA template and the neighboring bases.
The antioxidant activity expressed by A. salicina extracts may provide a common mechanism for inhibiting the mutagenicity of both B(a)P and 2-AA.
Recently, we investigated the mutagenicity of riddelliine, a representative genotoxic PA, in Big Blue rat liver.
Different QSTR techniques were employed to develop models for the prediction of mutagenicity of nitroarenes using a diverse set of 197 nitro aromatic and hetero aromatic molecules.
Thus, the appearance of this double mutant in our screening suggests that the mutagenicity of ENU is of a sufficiently high level for saturation mutagenesis.
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