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The available data show no bacterial mutagenicity for 1-pentene [ 5].
Studies of genotoxicity and carcinogenicity of nitro aromatic hydrocarbons focus on their high mutagenicity for bacteria and mammalian cells.
Alexander and Alexander [1999] reported a net decrease in mutagenicity for PAH-contaminated soil as the soil PAHs age.
The absence of mutagenicity for OS-EL in the tested S. typhimurium strains indicates that OS-EL does not affect the structural integrity of DNA.
The moderately polar chemical fraction of the particulates contained more than 50% of the direct acting Ames assay mutagenicity for the total extract.
Similar studies include that of Morelli et al. [2001], who observed a similar pattern of increasing and decreasing Salmonella mutagenicity for sludge-amended soils contaminated with PAHs [ Morelli et al., 2001].
Similar(51)
Coal tar itself is a powerful mutagen: The mutagenicity index for coal tar is about 1000 times that of asphalt cements.
The purpose of this work is to develop a quantum mechanically based quantitative structure activity relationship (QMQSAR or QSAR hereafter) adequate to predict and explain Ames TA100-derived mutagenicities for a number of organic molecules.
For instance, for presented in Figure 6 examples the improvement in DSC is 0.12 for carcinogenicity, 0.18 for mutagenicity and 0.21 for phospholipidosis.
Kazius et al.[34] derived a series of toxicophores for mutagenicity from a dataset of 4337 structures identifying a total of 29 toxicophores, 19 general and 10 additional.
Subsequently, assays for mutagenicity became proxies for tests of carcinogenicity, with the Ames test, performed in a bacterial system, as a well-known example [ 7].
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