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Classic population genetics theory establishes the equilibrium frequency of a sequence state is governed by the relationship between mutagenicity and functional significance.
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Unlike many bioactivities, mutagenicity can be linked to very specific chemical structure fragments and functional groups, usually referred to as toxicophores, which interfere with DNA [14 16].
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Concerns include the potential for acquired hypersensitivity, mutagenicity, and carcinogenicity.
Thus, substructures associated with mutagenicity in Salmonella are also present in carcinogens and agents active in other mutagenicity and genotoxicity assays.
This paper describes the implementation of ITS mutagenicity and carcinogenicity in the public OSIRIS webtool.
As an example, Num_AromaticBonds only exists in the mutagenicity and hERG datasets, while ADMET_Absorption_Level only exists in the antiTB and mutagenicity datasets.
Currently, there is a growing interest in environmental mutagenicity and carcinogenicity research.
"Quantitative modelling approaches for understanding and predicting mutagenicity and carcinogenicity" Rome, 3-5 September 1997.
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