Total mutagenic activity, which measures mutagenicity from all meat-related mutagens, was also estimated (Ferrucci et al, 2010).
The authors reported a selection bias, in which registrant-submitted studies on atrazine mutagenicity were all negative (no mutagenic activity), whereas over a dozen studies in the published literature reported mutagenic activity.
While halothane was without mutagenic activity in the Salmonella mutagenicity assay, even in the presence of microsomal fractions, the urines of anesthesiologists induced mutations of the base-substitution type.
In another study, MeOH, hydromethanol and chloroform extracts of B. intermedia were assessed for mutagenicity by the Ames test and mutagenic activity was not positively identified, in any extract, but the MeOH extract showed signs of mutagenicity to the strains TA98 (+S9,-S9) and TA100 (-S9).
Studies have indicated that foods exposed to drying, frying, roasting, baking, and broiling conditions possess net mutagenic activity as assessed by the Ames/Salmonella/microsome mutagenicity test and the chromosome aberration assay with Chinese hamster ovary (CHO) cells.
We used the Salmonella/microsome mutagenicity assay to test the new compounds for mutagenic activity.
Although the mutagenicities of CPAP and acephenanthrylene are similar, the mutagenic activity of CPAA is an order of magnitude greater than that of aceanthyrlene.
These strains are widely used for mutagenicity screening and have been shown to detect the mutagenic activity of benzidine analogs.
Like Cr VI), captan and folpet exhibit mutagenic activity in vitro, but evidence for in vivo mutagenicity is equivocal or negative (Arce et al., 2010; Bernard & Gordon, 2000).
CSC samples were tested for mutagenic activity using the preincubation version of the Salmonella mutagenicity assay as described in Mortelmans and Zeiger [ 2000].
