Sentence examples for mutagenic using the from inspiring English sources

Notably, all of the amino acid mutations produced by the missense mutations are predicted to be mutagenic, using the SIFT tool, which sorts intolerant from tolerant substitutions on the basis of conservation of the particular amino acid in related proteins (Ng and Henikoff 2001).

Therefore, assessments of the mutagenic activity using the S9 fraction allowed us to reject the concept that this activity might be exerted by metabolites of the compounds evaluated.

CSC samples were tested for mutagenic activity using the preincubation version of the Salmonella mutagenicity assay as described in Mortelmans and Zeiger [ 2000].

We investigated the production of mutagenic lesions using the pSP189 shuttle-vector system.

Point mutation of WT1A was performed by site-directed mutagenic PCR, using the PCB6+WT1A construct as the template [ 38].

Previously reported procedures for whole-plasmid, mutagenic PCR using the entire plasmid as template and back-to-back primer set resulted in linear DNA products, necessitating a separate ligation step to generate circular plasmids before transforming the host cell.

In vitro studies indicate coumaphos is not mutagenic using either Salmonella typhimurium or Escherichia coli assays with and without metabolic activation (U.S. EPA 1996).

In addition, these fluids often contain a variety of organic dyes (some of which may be mutagenic) used as coloring agents and the mixture of chemicals in embalming fluids has changed over the years.

A sensitive mutagenic assay system using the human hamster hybrid AL cells was used for the study.

Reported pathogenic stop mutations related to breast and ovarian cancer were introduced by a mutagenic PCR strategy using the wild type DNA as template [ 28].

The predicted bovine miR-27b seed-site was mutated with mutagenic primers by using the Quick Change Multisite mutagenesis kit (Stratagene, Waldbronn, Germany); mutations were confirmed by sequence analysis.