Sentence examples for mutagenic process from inspiring English sources

To bolster the sensitivity of this system for detecting mutagenesis of weak mutagens like PQ, and to provide a tool for mechanistic evaluation of the mutagenic process, we constructed a new AS52-derived cell line defective for 8OG DNA repair.

In these cases, strain engineering can be alternatively carried out using "inverse metabolic engineering", an approach that first generates genetic diversity by subjecting a population of cells to a particular mutagenic process, and then utilizes genetic screens or selections to identify the clones exhibiting the desired phenotype.

The diversity of the pathologies due to NUMT insertions reflects a mutagenic process that can target a large spectrum of genes.

The mutation pattern of the spermatozoa suggests a unique mutagenic process in the male germ line both spontaneously and following B[a]P-exposure.

The very low level of InsGs (Table 4) and clonally excluded InsGs (Table 3) among the liver cII-mutants in the same individuals substantiate the notion that the mutagenic process may be unique to the male germ line.

These results confirm a critical role for G5-SSR426 enhancing the mutagenic process of mucA in MRS-deficient cells, and shed light on another mechanism, the SSR- localized hypermutability, contributing to mucoid conversion in P. aeruginosa.

Now, next-generation sequencing technology enables us to observe in detail the DNA-sequence-level effects of well-known mutagens, such as ultraviolet radiation and tobacco smoke, as well as endogenous mutagenic processes, such as those involving activated DNA cytidine deaminases (APOBECs).

Since one hit must be in the gene that is mutated, the other hit could be responsible for the induction of error-prone, mutagenic processes.

To overcome some limitations of this experimental setup we developed a new adaptive mutation assay that allows a screening for mutagenic processes during a more regular cell cycle arrest induced by the lack of a fermentable carbon source.

Analyzing whole-genome sequences of 590 tumors from 14 different cancer types, we reveal widespread asymmetries across mutagenic processes, with transcriptional ("T-class") asymmetry dominating UV-, smoking-, and liver-cancer-associated mutations and replicative ("R-class") asymmetry dominating POLE-, andBEC-, and MSI-associated mutations.

These observations highlight the potential of large scale sequencing for revealing and elucidating mutagenic processes operative in individual human cancers.