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Crotonaldehyde is mutagenic in bacteria (73), genotoxic and mutagenic in human lymphoblasts (74), and induces liver tumors in rodents (75).
Although DEB is a minor metabolite of BD, it is 50- to 100-fold more genotoxic and mutagenic in human cells than the monoepoxide metabolites, EB and EBD.
In conclusion, the C8-dG-ABA adduct formed by 3-NBA was found to be mutagenic in human (HEK293T) and simian (COS-7) kidney cells.
However, in contrast to many other intercalating drugs, quinacrine does not induce DNA damage and is not considered to be mutagenic in human cells.
Since G[8,5-Me]T is mutagenic in human cells, we decided to investigate if hpol η can bypass this lesion and, in the event of translesion synthesis, the specificity of nucleotide incorporation.
Cr III -mediated Cr III -mediatedNA with peptide glutathione or single amino acids were mutagenic in human cells, with a relatiofship of higher molecular weight of the peptiDNAamino acid correlating with a more peptidemutaglutathionense.
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Thus, the remaining open question is whether BD is mutagenic in humans.
Also, extended use of chemical pesticides not only often causes to the development of resistance (to pesticides) in insect pests, pathogens, and nematodes but also leads to carcinogenic, teratogenic, and mutagenic effects in human and animals as well.
Genetic biomonitoring provides us with an indication of mutagenic effectiveness in human somatic cells.
Bromodichloromethane has been shown to induce mutagenic activity in human urine (Leavens et al. 2007).
These PAHs were also tested for mutagenic activity in human cells.
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