Sentence examples for mutagenic efficiency of from inspiring English sources
Thus, it is difficult to formulate valid generalizations regarding mutagenic efficiency of specific DNA lesions or mechanisms through which they are created.
To assess the mutagenic efficiency of our system, we have performed qRT-PCR to quantify the levels of wild type read-through transcript in 9 lines.
The mutagenic efficiency of lacZ in bone marrow was found to be 25-fold higher than that for RETCD24− (Table II).
Given the low basal mutagenic efficiency of KBrO3, the comparably weak protective effect of frataxin in this particular case is not really surprising.
Both the A of the branch point and the intron-terminal AG dinucleotide are considered invariant; therefore, one may be able to enhance the mutagenic efficiency of U3Neo vectors by altering these nucleotides.
Arylamine-C8-deoxyguanosine substitution was correlated with frameshift reversions induced by these agents, with the lesions showing a relative order of mutagenic efficiency of ABZ>AF≅2-NA>ABP.
Although measurement of the proportions of cell types in the bone marrow that are committed to becoming RETs would prove challenging, this information would permit a better estimate of mutagenic efficiency for the Pig-a endpoint.
Accordingly, the mutagenic efficiency for Pig-a could not be adjusted for the proportion of bone marrow DNA adducts in RET or RBC progenitor cells.
Mutagenic efficiency, indicative of the rate of conversion of DNA adducts into mutations (expressed as number of mutants per DNA adduct in 10 nucleotides at a given dose), was calculated for lacZ mutants in bone marrow and mutant Pig-a phenotypes in RETs.
We estimate that mutagenic efficiency (i.e., rate of conversion of adducts into mutations) was much lower for Pig-a compared to lacZ, and speculate that this difference is likely explained by differences in repair capacity between the gene targets, and differences in the cell populations sampled for Pig-a versus lacZ.
The rate of conversion of DNA adducts into mutations, estimated using the ratio of mutant frequency to adduct frequency, and denoted as mutagenic efficiency, was calculated for both of these mutation targets in order to compare susceptibility of the two loci.
