It would have been prudent to spend a few hundred thousand dollars to determine the mutagenic effect of low-level tritium radiation before spending millions on a cleanup.
This indicated the lack of direct mutagenic effect of cordycepin on TA98 bacteria and would imply that cordycepin is a non-mutagenic agent.
Table 1 Mutagenic effect of water samples from different sites of Harike wetland in TA 98 tester strain of Salmonella typhimurium in Ames assay S. no.
A critical analysis of results showed that the mutagenic effect of water samples from the different sites was higher than their genotoxic effect except for site 8 and 11, which showed slightly higher values of genotoxicity as compared to mutagenicity.
At a more specific level, hypothesis h6 tells us that the mutagenic effect of the aromatic nitro group (h1) can be mitigated by the presence of a sulfonic acid group in the meta position.
The lethal effect in yeast seems to be related to the mutagenic effect of the recombinant HIV-1 IN, most probably via the non-sequence-specific endonucleolytic activity carried by this enzyme.
This might be attributed to the mutagenic effect of ribavirin [59].
The mutagenic effect of chrysotile exposure was detected by the micronucleus assay.
In fact, the mutagenic effect of ribavirin has been confirmed very recently [59], although this is still a controversial issue [60].
We have detected a global increase in the levels of synonymous substitutions after failed treatment, which could be due to the mutagenic effect of ribavirin.
Second, the data presented here support models in which, at least for frameshift reversion, Pols I, II, and III compete with and dampen the mutagenic effect of Pol IV.
