Sentence examples for mutagenesis support a from inspiring English sources

The exact membrane topology remains controversial: in vitro translation studies using membrane insertion scanning suggested a 9-transmembrane (TM) topology, whereas N-glycosylation scanning mutagenesis and dual-label epitope insertion scanning mutagenesis support a 7-TM topology [ 13- 19].

Our results, both by bioinformatics and site-directed mutagenesis, support the hypothesis that VP2 contain a NLS and named as NSL2.

Taken together, our mutagenesis results support a central role of Kvβ2 in Kv1.2 axonal transport.

Using likelihood reconstruction of ancestral sequences and site-saturation combinatorial mutagenesis, supported by Mph crystal structures, we determine that two non-obvious mutations in combination expand the substrate range.

The docking studies also indicate that P450cin and346 Arg102g102 are important, and the mutagenesis supports these predictions.

To detect intramolecular distances within the fibrils, cysteines were introduced pairwise in the monomeric protein by site-directed mutagenesis (Supporting Information).

Site-directed mutagenesis did not support a role for a structural link between 14-3-3 14-3-3 14-3-3binding site in regulandon of catheytic activity (Supplementary Fig. 9 and Supplementary Table 2).

Taken together, the mutagenesis studies support the notion that the N-terminus of Ets serves as a weak ligand for the Φhyd site of the DRS of ERK2.

Biochemical and mutagenesis studies support this arrangement [5], [6].

Mutagenesis data support our mechanistic proposal.

Experimental evidence based on isothermal titration calorimetry and mutagenesis studies support the presence of two metal-binding sites [ 17, 18].