Sentence examples for mutagenesis studies mapped from inspiring English sources

Furthermore, mutagenesis studies mapped another 8 amino acids around the binding interface of VA387 affecting the binding function [35], while only 2 such residues of Norwalk virus were found (this report).

Prior to CD4 gp120 crystal structures, mutagenesis studies mapped the gp120 binding sites on CD4.

Mutagenesis and structure-activity relationship studies map the NSC-658497 site of action to the SOS1 catalytic site, and define the chemical moieties in the inhibitor essential for the activity.

In Toxoplasma, the combination of forward genetics and WGS has extended Pfefferkorn's pioneering chemical mutagenesis studies to map drug resistance genes [ 33, 34] and biological phenotypes in invasion and egress [ 7, 13].

We applied the approach to PDZ, SH3 and kinase domains, and evaluated the results using both residue proximity in co-crystal structures and verified binding specificity maps from mutagenesis studies.

Biophysical, genome mapping, and mutagenesis studies of FoxA1 reveals two different modes of binding to mitotic chromatin: Specific binding, at sites that continue to be bound from interphase, and nonspecific binding, whereby due to intrinsic chromatin affinity, FoxA1 remains in the genomic vicinity of its interphase target genes.

With some notable exceptions, the results of extensive mutagenesis studies that were performed on the truncated HHRz map to results on the more extended versions of the ribozyme, indicating that the lower rates achieved in the absence of the tertiary interaction reflect a lower population for the active ribozyme but the same overall mechanism.

Mass spectrometry and mutagenesis studies of the full-length mFOXO3 or the P2 and P3 fragments from the in vitro kinase assay mapped the CAMKIIA phosphorylation sites to S252, S279, and S298 (not shown).

These regions may be good targets for mutagenesis studies aiming at disrupting protein protein interfaces.

Mutagenesis studies could help analyse the specificity of NHA-I.

Mutagenesis studies were conducted to further verify the binding of Fg α561−575 to Bbp273−598.