Sentence examples for mutagenesis screening of from inspiring English sources

Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammary placodes in embryonic skin.

Taken together, these results suggest that mutagenesis screening of the GPI-anchor biosynthetic pathway has almost been saturated with the 22 known essential genes.

A transposon mutagenesis screening of Mycobacterium tuberculosis showed the structural proteasomal genes of this closely related bacterium to be involved in their response toward oxidative and nitrosative stresses [ 27].

Yersinia RovA was first identified as a regulator of invasion factor expression in a transposon mutagenesis screen of Y. enterocolitica using an inv::phoA reporter to monitor inv expression [5].

Numerous mutants identified in our random mutagenesis screen of functionally deficient CRY1 and CRY2 bear mutations of amino acids located outside these sites (McCarthy et al., 2009).

Insertion/deletion mutagenesis screens of the Drosophila X chromosome revealed several key developmental genes associated with embryonic/first instar larval cuticle development [ 18].

Then, we performed a comprehensive alanine mutagenesis screen of all highly conserved acidic residues in TMEM16A that are predicted to be accessible to the cytoplasm.

Mutagenesis screens of BRAF V600E containing cell lines identified constitutively active MEK1 mutations that conferred resistance to either MEK or BRAF inhibitors [ 99, 100].

Recently, somatic mutations in the heterotrimeric G protein alpha subunit q (GNAQ) have been found to be associated with dominant dark skin in a large-scale mutagenesis screen of inbred C3HeB/FeJ mice (Van Raamsdonk et al, 2004).

When Nusslein-Vollhard and Wieschaus first conducted their saturation mutagenesis screen of Drosophila in the late 1970s, the prospect of having a phenotypic characterisation for a mutation in every gene in a mammal seemed distant to the point of being unattainable.

An insertional mutagenesis screen of the F. graminearum wild-type strain PH-1 was completed using a linearised plasmid vector containing the hygromycin phosphotransferase gene under control of the trpC promoter.