Sentence examples for mutagenesis screen of from inspiring English sources

The Clock mutation in mice was identified by an N-ethyl-N-nitrosourea mutagenesis screen of circadian periods31.

Here we report that asteroid, a gene identified in an ethylnitrosourea mutagenesis screen of zebrafish larvae for auditory/vestibular mutants, encodes vesicular glutamate transporter 3 (Vglut3).

Yersinia RovA was first identified as a regulator of invasion factor expression in a transposon mutagenesis screen of Y. enterocolitica using an inv::phoA reporter to monitor inv expression [5].

Numerous mutants identified in our random mutagenesis screen of functionally deficient CRY1 and CRY2 bear mutations of amino acids located outside these sites (McCarthy et al., 2009).

Then, we performed a comprehensive alanine mutagenesis screen of all highly conserved acidic residues in TMEM16A that are predicted to be accessible to the cytoplasm.

Recently, somatic mutations in the heterotrimeric G protein alpha subunit q (GNAQ) have been found to be associated with dominant dark skin in a large-scale mutagenesis screen of inbred C3HeB/FeJ mice (Van Raamsdonk et al, 2004).

Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammary placodes in embryonic skin.

Insertion/deletion mutagenesis screens of the Drosophila X chromosome revealed several key developmental genes associated with embryonic/first instar larval cuticle development [ 18].

Mutagenesis screens of BRAF V600E containing cell lines identified constitutively active MEK1 mutations that conferred resistance to either MEK or BRAF inhibitors [ 99, 100].

Taken together, these results suggest that mutagenesis screening of the GPI-anchor biosynthetic pathway has almost been saturated with the 22 known essential genes.

A transposon mutagenesis screening of Mycobacterium tuberculosis showed the structural proteasomal genes of this closely related bacterium to be involved in their response toward oxidative and nitrosative stresses [ 27].