Sentence examples for mutagenesis rate from inspiring English sources

We found that <3 to 4 days of administration of the virus, the mutagenesis rate of Pcsk9 in the liver was as high as >50%.

Finally, we generated null alleles of HP1a using optimized parameters through homology-directed repair and achieved an overall mutagenesis rate significantly higher than previously reported.

Another complementary assay was based on astonishing phenotypes of an mms2 (Broomfield et al. [2001]) or ubc13 (Brusky et al. [2000]) mutant with massive increase in the spontaneous mutagenesis rate, providing strong evidence that UBC13 plays a critical role in maintaining genomic stability of host cells.

Serial amplification was performed on the entire 240-nt gene-encoding region with a target mutagenesis rate of 3.5% per amino acid position.

Analysis of the individual sequences revealed that the observed mutagenesis rate closely approximated the expected rate (3.7% versus 3.5% per amino acid position, respectively) with a roughly equal number of transitions and transversions.

Mutagenesis rate is defined as the ratio of mutant colonies to total colonies [ 5].

Mutagenesis rates were calculated using the Drake Formula [65].

The calculated mutagenesis rates are 91- and 2000-fold higher than the spontaneous mutation rate of 6.0 × 10−9 mutations/effective site calculated for Arabidopsis.

Endothelial cells have low mutagenesis rates and are unable to acquire multidrug resistance to cancer therapeutics, making angiogenesis an attractive anticancer target [ 4].

However, the mutagenesis rates of Cas9H840A flies were much lower compared with Cas9D10A flies, reaching only up to 1.5% (Table 2).

The presence of such inactive protease variants in plant genomes suggests that they might have acquired roles other than proteolysis, resulting in altered evolutionary pressure on the protease domain and the potential for higher mutagenesis rates.