Sentence examples for mutagenesis of human from inspiring English sources

Iskow, R. C. et al. Natural mutagenesis of human genomes by endogenous retrotransposons.

McKendry, R. et al. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both α and γ interferons.

Site-directed mutagenesis of human K19 cDNA (GenBank accession number NM_002276.4) to convert Tyr391→Phe, and Tyr4→Phe was performed using QuikChange kit (Stratagene) and confirmed by DNA sequencing.

Site-directed mutagenesis of human αB crystallin demonstrated that chaperone activity was independent of complex size and that chaperone activity required exposure of the same interactive domains on the surface of αB crystallin that were used in assembly [26], [27], [29], [31], [37].

To decipher the mechanism by which the novel Q1069R mutation might be responsible for the absence of plasma (and perhaps tissue) ACE in the affected individuals, we performed site-directed mutagenesis of human recombinant somatic ACE, generated this mutant of somatic ACE in CHO cells, and compared the biochemical and immunological characteristics of this mutant with WT somatic ACE.

The oligonucleotide primers used for the mutagenesis of human CX3CL1 are the following.

No mutagenesis experiments of human GAT1 (UniProtKB, P30531) exist in the literature.

The mechanism of trehalose dimycolate binding to the C-type carbohydrate-recognition domain in human mincle has been investigated using a series of synthetic analogs of trehalose dimycolate and site-directed mutagenesis of the human protein.

Using a genetic selection system established in the yeast Saccharomyces cerevisiae, we have isolated, by random mutagenesis of the human estrogen receptor (ER), six mutants that display constitutive transcriptional activity.

Oligonucleotides for tyrosine to phenylalanine mutagenesis of the human ZnT4 were the following: Y355F mutant: sense-5' andantisense-5'-ATTTAAATCTTCGACTGAAAATACATCTTCTATTTTCAT-3''-antisense-5'-ATTTAAATCTTCGACTGAAAATACATCTTCTATTTTCAT-3'

Oligonucleotides for tyrosine to phenylalanine mutagenesis of the human ZnT3 were the following: Y330F mutant: sense-5'-GCCCTTACGCTCACTTTCCATGTTGCCTCTGCAC-3' and antisense-5'-GTGCAGAGGCAACATGGAAAGTGAGCGTAAGGGC-3'.