Sentence examples for mutagenesis in human from inspiring English sources

Chatterjee, N., Lin, Y., Yotnda, P. & Wilson, J. H. Environmental stress induces trinucleotide repeat mutagenesis in human cells by Alt-nonhomologous end joining repair.

In the following sections, we analyze mature dinucleotide microsatellite mutagenesis in human cells to elucidate the mechanisms underlying their mutability.

Therefore, the study of a single DNA polymerase cannot be used to directly describe microsatellite mutagenesis in human cells.

For example, a number of surrogate assays have been developed to evaluate the risk of insertional mutagenesis in human HSCs following transplant.

To investigate the molecular mechanism of C8-dG-ABA mutagenesis in human cells, we have replicated a plasmid containing a single C8-dG-ABA in human embryonic kidney 293T (HEK293T) cells, which yielded 14% mutant progeny.

Consistently positive results have been found in all standard mutagenicity tests, 102) including a reverse mutation assay in Salmonella, HPRT mutagenesis in hamster V79 and CHO cells, 104) TK mutagenesis in human lymphoma cells, 105) and in vivo assays in transgenic animals.

Insertional mutagenesis in humans has been proven to occur in patients who have received retroviral therapy for SCID-X1.

Therefore, germ-cell mutagenesis in humans can most adequately be represented by an in vivo mammalian germ-cell test system.

LINE-1 (L1) retrotransposons are a major source of endogenous mutagenesis in humans (Burns and Boeke, 2012; Levin and Moran, 2011).

Human DNA TE activity subsided over 37 million years ago [ 5]; as a result, DNA TEs no longer contribute significantly to the ongoing mutagenesis in humans.

Although DEB is the most potent mutagen, reports have suggested that it is not a significant factor in in vivo mutagenesis in humans (Bond et al. 1995).