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Targeted mutagenesis implies that specific nucleotides are preferentially mutated at high frequencies.
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N2PR −110 only responded to β-catenin and the results from the site-directed mutagenesis imply that β-catenin affect the Notch-2 core promoter via non-canonical Wnt signaling.
The results reported by Daxinger et al. [ 38] imply that gene silencing mediated by 35S promoter homology between transgenes and T-DNAs used for insertional mutagenesis is a common problem and occurs in tagged lines from different collections.
Second, biased NTP pools are a well known factor for mutagenesis [15], implying that some of the extension products, which were used for assessing polymerase activity, are actually the products of mutation synthesis.
The 'slow' scenario implies that, as far as mtDNA mutagenesis is concerned, we need to preserve mtDNA during early years or even during development and to be less worried about mutations that arise in older individuals.
Furthermore, the enhancer-less nature of the A2UCOE implies that it should possess far lower insertional mutagenesis activation potential than commonly used enhancer-associated viral and nonviral promoters.
This divergence implies that for internal and last exons in mammals, the principal biological role of mCG is mutagenesis.
This implies that the increased lifespan of treated mice allows for additional rounds of bacterial replication, selection, and mutagenesis, ultimately resulting in an increased frequency of permanent drug-resistant mutants (note that successful antibiotic treatment of mice infected with TIVAR − bacteria precluded recovery of PMBr mutants from these animals (day 10)).
"It implies that you can give up.
Sometimes it implies that overtime is involved.
It implies that lessons have been learned.
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