Sentence examples for mutagenesis demonstrating that from inspiring English sources

Specific GAG binding sites of several chemokines have been delineated by mutagenesis, demonstrating that these sites are either distinct, or partially overlap with receptor binding sites.

Structure-guided mutagenesis demonstrated that the liposome-leakage and pore-forming activities of the gasdermin-N domain are required for pyroptosis.

Subunit-specific mutagenesis demonstrated that the presence of the N136A mutation in the p51 subunit alone was sufficient to cause degradation of RT within the virus particle.

Mutagenesis demonstrated that the two RAREs work synergistically in RA inducibility of cyp26a1.

Site-directed mutagenesis demonstrated that His127, Asp156 and Ser263 in Domain 1 form the catalytic triad of EspP.

A number of studies based on deletion and site-directed mutagenesis demonstrated that the central helices in these BCL-2 family proteins are required for pore formation and for both cytoprotection and apoptosis induction [29], [30], [31], [32], [33].

Promoter reporter experiments, electrophoretic mobility shift assays (EMSA) and site directed mutagenesis demonstrate that a Foxi1 expression vector can trans-activate an a4-promoter reporter construct in a dose dependent manner.

Finally, site-directed mutagenesis demonstrates that the PIP box is important for SMCX association with PCNA.

Protein sequence alignment, structure modeling and site-directed mutagenesis demonstrated that Ser, Gly, Asn, Asp and His residues composed the active centre of 'AcTesA.

Site-directed mutagenesis demonstrated that phosphorylation of Ser, but not the previously reported PKA site Ser, was required for 14-3-3 14-3-3 14-3-3

Structure modelling and site-directed mutagenesis demonstrated that hydrogen bonding and hydrophobic interactions were responsible for the increased thermostability imparted by Q10Y.