Sentence examples for mutagenesis demonstrates that from inspiring English sources

Finally, site-directed mutagenesis demonstrates that the PIP box is important for SMCX association with PCNA.

Here we found by difference Fourier transform infrared spectroscopy the appearance of Fermi-resonant X H stretch modes in light-minus-dark difference spectra; their assignment with N labeling and site-directed mutagenesis demonstrates that His166 is the SB proton acceptor during the photochemical reaction cycle of the wild-type SRI HtrI complex.

Subunit-specific mutagenesis demonstrated that the presence of the N136A mutation in the p51 subunit alone was sufficient to cause degradation of RT within the virus particle.

Site-directed mutagenesis demonstrated that His127, Asp156 and Ser263 in Domain 1 form the catalytic triad of EspP.

Specific GAG binding sites of several chemokines have been delineated by mutagenesis, demonstrating that these sites are either distinct, or partially overlap with receptor binding sites.

A number of studies based on deletion and site-directed mutagenesis demonstrated that the central helices in these BCL-2 family proteins are required for pore formation and for both cytoprotection and apoptosis induction [29], [30], [31], [32], [33].

Promoter reporter experiments, electrophoretic mobility shift assays (EMSA) and site directed mutagenesis demonstrate that a Foxi1 expression vector can trans-activate an a4-promoter reporter construct in a dose dependent manner.

Protein sequence alignment, structure modeling and site-directed mutagenesis demonstrated that Ser, Gly, Asn, Asp and His residues composed the active centre of 'AcTesA.

Site-directed mutagenesis demonstrated that phosphorylation of Ser, but not the previously reported PKA site Ser, was required for 14-3-3 14-3-3 14-3-3

Structure modelling and site-directed mutagenesis demonstrated that hydrogen bonding and hydrophobic interactions were responsible for the increased thermostability imparted by Q10Y.

Site-directed mutagenesis demonstrated that this DNA sequence was required for maximal transactivation while the ChIP assay showed that Brn-3b protein binds to the HSP27 promoter in vivo.