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The structural studies are consistent with mutagenesis data on this enzyme.
There were two accepted ways of plotting mutagenesis data on log-log plots, i.e., mutants/survivors versus survival or versus dose.
The structural features of interface II are consistent with mutagenesis data on the functional roles of interface residues (Figure 1C).
Together with our previous mutagenesis data on ICL2 and ICL3 we provide here the first systematically completed map of potential interfaces between TSHR and heterotrimeric G-protein.
The homology model of the IL-3:receptor complex generated in this study provides a molecular framework to analyze a large body of mutagenesis data on the roles of specific residues in IL-3:receptor complex formation and function.
The observed binding mode is consistent with most of the mutagenesis data on this complex.
Similar(53)
Our mutagenesis data for PepTSt are consistent with analogous studies on PepT1 and PepT2, which concluded the N-terminal helices dictated peptide binding and affinity characteristics (Döring et al, 1996, 2002; Fei et al, 1998).
Nevertheless, our mutagenesis data based on L3MBTL1 suggested that the histone peptides could not bind to MBT repeats in any orientation.
To the best of our knowledge, GATMD is the first publicly accessible, comprehensive mutagenesis data resource on any membrane transport protein.
The first hydroxynitrile lyase whose reaction mechanism was elucidated on the basis of comprehensive structural, kinetic, and mutagenesis data is the one from H. brasiliensis, which exhibits a stereospecificity opposite to FAD−HNLs (39− 41).
This is consistent with mutagenesis data from other groups on the full length GNE protein [11], [18].
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