Sentence examples for mutagenesis data and from inspiring English sources

The results are consistent with current site-directed mutagenesis data and with the observed selectivity of TAK779 for CCR5 over CCR1 and CCR2.

In the most compatible docking pose, coumarin forms H-bonds with both N93 and N247, π-π stacking interaction with F181, and hydrophobic interactions with F89 (distance of 3.7 Å). 2D representation of predicted binding modes, mutagenesis data and residues involved in the binding of ggTas2r1 agonists.

The large differences in affinity coupled with the availability of extensive mutagenesis data and high-resolution crystal structures for the TEM-1/BLIP and SHV-1/BLIP complexes make them attractive systems for the further development of computational design methodology.

The obtained results highlight the key residues involved in binding sites of both agonists and antagonists, confirming the mutagenesis data and giving new suggestions for the rational design of selective ligands.

The publication of the crystal structures of zebrafish P2X4 receptor in inactive and ATP-bound active forms provided structural data for the analysis of the receptor structure, the interpretation of mutagenesis data, and the depiction of ligand binding and receptor activation mechanism.

The obtained results highlight the hydrophobic or aromatic residues involved in S6 transmembrane domain and the base of the pore helix of KCNQ1, confirming the mutagenesis data and pharmacophore model, and giving new suggestions for the rational design of novel KCNQ1 ligands.

We provide the first integrated view of the pharmacological, biochemical, and structural data available for this receptor family, by mapping onto the relevant crystal structures all site-directed mutagenesis data, curated and deposited at the GPCR database (available through http://www.gpcrdb.org).

The authors have chosen to present the mutagenesis data first and the structural results second.

To assure ourselves that the difference in distribution between the mutagen-derived SNVs and the in vitro culture derived SNVs is not due to sample size, we repeatedly downsampled the in vitro set to match the number of SNVs in the two mutagenesis data sets and this did not affect the conclusions.

Based on the deletion mapping and mutagenesis data (Figures 1 and 3), the active NS5A peptide mutant (S158E) and a control (152 167scr) peptide were synthesized and tested for HIV inhibition when added to cells 24 hrs prior to HIV infection (concentration up to 50 µg/mL).

The NMR and mutagenesis data suggested that α4 and α5 are dynamic and that the relationship between the two helices and the α/β-core of the PD likely plays a role in activation.