Sentence examples for mutagenesis by reducing from inspiring English sources
We investigated the possibility that dnaE915 reduces Pol IV-dependent mutagenesis by reducing SOS expression in stationary-phase, stressed cells.
Alternatively, reduced spontaneous SOS induction has been demonstrated in dnaE915 cells [46], and this might lower mutagenesis by reducing expression of dinB encoding Pol IV.
Since the experimenter can control the mutagenesis directly by reducing the concentration or time of mutagenesis, we suggest that future phenotype sequencing experiments should use a substantially lower mutagenesis density than we employed, to boost the signal-to-noise ratio.
Thus, minimizing cellular HO production is better suited for cancer prevention by reducing the long-term accumulation of oxidative DNA damage and mutagenesis.
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We inactivated the standard slippery sequence by site-directed mutagenesis; this reduced frameshifting efficiency by 5-fold in the luciferase reporter assay.
Given the importance of RbBP5 and Ash2L interaction in the overall H3 K4 methylation, we next tested whether disrupting RbBP5 and Ash2L interaction by site-directed mutagenesis reduced SAM binding by Ash2L.
When the gene encoding the new lipopeptide was knocked out in C. fungivorans Ter331 by site-directed mutagenesis, reduced suppression was observed (Fig. 5d).
Consistent with this notion, when linker docking at AAA5 is abolished by mutagenesis, dynein displays reduced velocity and prolonged microtubule attachments (Schmidt et al., 2012), reminiscent of Lis1's effects.
Furthermore, treatment of bystander cells with NS-398, a specific inhibitor of COX-2, reduces mutagenesis by more than six-fold over the corresponding controls.
