Sentence examples for mutagenesis and functional from inspiring English sources

These predictions were validated by mutagenesis and functional analysis.

Residue important for capsaicin activation identified by mutagenesis and functional studies are colored in orange.

Docking of tRNAAla on AlaRS shows critical contacts with the three domains, consistent with previous mutagenesis and functional data.

Site-directed mutagenesis and functional assays prove the involvement of the Zn and flexible loop in catalysis.

Mutagenesis and functional analysis evidenced two residues, at positions 47 and 58 of the VH chain, playing a crucial role in the antigen binding recognition.

This is in close agreement with mutagenesis and functional studies: residues Y511, S512 and T550 identified in these studies locate right around the pocket (Jordt and Julius, 2002; Gavva et al., 2004), and dramatic perturbations to intracellular structures often leave capsaicin activation undisturbed (Ma et al., 2016).

The data from extensive mutagenesis, binding and functional studies reveal the importance of these residues and also provide a structural explanation for their critical roles.

However, site-directed mutagenesis studies and functional assays of scorpion α-toxins have shown that there is a functional site composed of the five-residue reverse turn (Asp Cys) and the C-terminal segment, and that the conserved hydrophobic surface may be involved in maintaining the stability of the protein and its biological activity.

In a typical structure-function relation study, the primary structure of proteins or nucleic acids is changed by mutagenesis and its functional effect is measured via biochemical means.

The recent emergence of massively parallel approaches for dense mutagenesis and the functional analysis of specific sequences [ 7] may enable a different paradigm, in which all possible variants of a clinically relevant gene are functionally tested in advance of ever having been observed in a patient.

QuikChange is a popular method for site-directed mutagenesis in structural and functional studies of proteins and nucleic acids.