Sentence examples for mutagenesis analysis of from inspiring English sources

Open image in new window Figure 4 Sequence alignment of BubR1 and mutagenesis analysis of the B56γ1-BubR1 B56γ1-BubR1

Site-specific mutagenesis analysis of C. necator PHA synthase had shown that the conserved cystein-319, aspartate-480 and histidine-508 of the class I synthase are required for enzyme activity.

We conclude that our approach, based on DSC and site-directed mutagenesis analysis of chimeric fusion proteins, may serve as a suitable tool to analyse the energetics of weak biomolecular interactions such as those involving SH3 domains.

Although improvements in vector design clearly lowered the risk of this insertional mutagenesis, analysis of potential genotoxicity and the consequences of vector integration remain important parameters for basic and translational research and most importantly for the clinic.

For understanding mechanism of action at the atomic level crystal structure provide valuable inside but lack of crystal structure of ion channel lead sequence analysis of different types of voltage dependent Ca2+ channel (VDCC) and we found identical/similar active site residues, which was confirmed by site-directed mutagenesis analysis of L-type Ca2+ channel (LCC).

Furthermore, site-directed mutagenesis analysis of an Arg46 G1u47 motif of SPLTI-a, based on amino acid sequence alignment with other PI-Is, indicated that Arg46 G1u47 of SPLTI is a novel reactive site for PI-I family conferring the trypsin-specific inhibitory activity.

To validate the crystallographic observations and evaluate the significance of individual interaction, we performed mutagenesis analysis on both sides of the PP2A B56 and BubR1 interface.

To address this apparent inconsistency and further elucidate the relationship between structure and HBGA binding patterns, we performed mutagenesis analysis on the role of the three conserved sites in HBGA binding of the Boxer virus.

Herein, we investigated gene expression of Photorhabdus temperata residing in the enduring infective juveniles of H. bacteriophora to determine bacterial survival strategies and performed mutagenesis analysis to evaluate the importance of selected genes in bacterial persistence in the nematode intestine.

We also performed in silico mutagenesis analysis to characterize the effects of oncogenic mutations on the negative regulators and to observe the cellular outcome (whether there is/is not inflammation).

These results were then filtered by information content of the alignment in the same way as the SWISS-PROT mutagenesis analysis to result in a list of ∼22,000 SNPs.